Heart Rate, Baroreflex Sensitivity and Cardiovascular Morbidity and Mortality in the Population

The aim of the present Paris Prospective Study III (PPS3) is (1) to assess the determinants of the regulation of heart rate and blood pressure variations and carotid properties (under different physiologic stimulations) and (2) to evaluate the respective contribution of heart rate, blood pressure variations and carotid properties to cardiovascular morbidity and mortality including sudden death during 10 years at least in healthy considered subjects.

Overall, 10 157 men and women have been recruited during May 2008 and June 2012 for an extensive clinical examination including a 2h holter electrocardiography (ECG), a carotid doppler echo tracking, a step test, as well as blood and DNA collections. Since then, the cardiovascular morbidity and mortality of the participants is being followed up for 10 years at least and will continue up to 2032.

Eligibility

Relevant conditions:

Community Based Study

Cardiovascular Disease

Sudden Death

Blood Pressure

If you aren't sure if you meet the criteria above speak to your healthcare professional. Criteria may be updated but not reflected here, do not hesitate to contact the study if you think are close to fitting criteria.

locations

Contact Information

Overall Contact

Xavier Jouven, MD, PhD

xavier.jouven@egp.aphp.fr

1 56 09 36 87

Jean-Philippe Empana, MD, PhD

jean-philippe.empana@inserm.fr

1 53 98 80 20

Data sourced from ClinicalTrials.gov