742040
Last Update Posted: 2008-08-27
Recruiting status is unknown
All Genders accepted | Under 18 Years |
50 Estimated Participants | No Expanded Access |
Interventional Study | Does not accept healthy volunteers |
Rapid Versus Prolonged Inpatient Up-Titration of Captopril
The primary objective of this study is to establish a safe and effective method of up-titration of captopril for hospital inpatients.
Angiotensin converting enzyme inhibitors (ACEi) are one of the most frequently prescribed pediatric cardiac medication and overall their safety in children is widely accepted. Pediatric formulary recommendations for ACEi suggest starting with a low initial dose (0.1 mg/kg), to avoid hypotension, and up-titration for a maintenance dose. However, side ranges are quoted for maintenance doses and no guidance is given as to the best method of up-titration, The physician is left uncertain of the optimal dose and how best to achieve it.
The ultimate goal of this study is to be in a position to provide physicians caring for children with heart disease information about how to safely up-titrate this widely used medication, and by doing so to improve dosing in the wider pediatric population.
Eligibility
Relevant conditions:
Heart Disease
If you aren't sure if you meet the criteria above speak to your healthcare professional. Criteria may be updated but not reflected here, do not hesitate to contact the study if you think are close to fitting criteria.
locations
Data sourced from ClinicalTrials.gov