Campylobacter Jejuni Challenge Model Development: Dose Ranging Study

The primary objective of this study is to establish a human Campylobacter jejuni infection model with the following characteristics:

1. Safe application

   1. Infectious period risk mitigated by close monitoring and prospectively applied early treatment criteria
   2. Potential post-infectious sequelae risk mitigated by appropriate strain and host selection

2. Campylobacteriosis attack rate of at least 75%

Secondary objectives are to determine humoral, cell-mediated, and mucosal immune responses in the newly established human C. jejuni infection model and evaluate short-term (< 3 mo) protection upon repeat exposure to homologous C. jejuni strain and assess immune responses associated with protection.