4975334
Last Update Posted: 2025-03-04
Recruiting
All Genders accepted | 18 Years-75 Years |
23 Estimated Participants | No Expanded Access |
Interventional Study | Does not accept healthy volunteers |
Opioid Antagonism in Hypogonadotropic Hypogonadism
The goal of this study is to evaluate the effects of opioid antagonists on the hypothalamic-pituitary-gonadal axis in subjects with idiopathic hypogonadotropic hypogonadism (HH).
Assignment: Each study subject will serve as their own control.
Delivery of Interventions:
Prior to the study visit, subjects will undergo a review of their medical history and screening laboratories.
During the study, the subjects will undergo the following:
Period 1: Undergo q10 min blood sampling for up to 12 hours
Period 2: Undergo q10 min blood sampling for up to 12 hours
- Receive a naloxone bolus followed by a naloxone infusion
Eligibility
Relevant conditions:
Hypogonadotropic Hypogonadism
If you aren't sure if you meet the criteria above speak to your healthcare professional. Criteria may be updated but not reflected here, do not hesitate to contact the trial if you think are close to fitting criteria.
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Data sourced from ClinicalTrials.gov