Possibia

4975334

Last Update Posted: 2025-03-04

Recruiting

All Genders

accepted

18 Years-75 Years

23 Estimated Participants

No Expanded Access

Interventional Study

Does not accept healthy volunteers

Opioid Antagonism in Hypogonadotropic Hypogonadism

The goal of this study is to evaluate the effects of opioid antagonists on the hypothalamic-pituitary-gonadal axis in subjects with idiopathic hypogonadotropic hypogonadism (HH).

Assignment: Each study subject will serve as their own control.

Delivery of Interventions:

  • Prior to the study visit, subjects will undergo a review of their medical history and screening laboratories.

  • During the study, the subjects will undergo the following:

    • Period 1: Undergo q10 min blood sampling for up to 12 hours

    • Period 2: Undergo q10 min blood sampling for up to 12 hours

      • Receive a naloxone bolus followed by a naloxone infusion

Eligibility

Relevant conditions:

Hypogonadotropic Hypogonadism

If you aren't sure if you meet the criteria above speak to your healthcare professional. Criteria may be updated but not reflected here, do not hesitate to contact the trial if you think are close to fitting criteria.

locations

Contact Information

Overall Contact

No valid contacts available

Data sourced from ClinicalTrials.gov