A Phase I/II Trial of UCB4594 in Participants With Advanced Cancer

This clinical trial is looking at UCB4594. This is the first time the drug is being tested in humans. UCB4594 is a type of drug called a monoclonal antibody. It has been designed to work by targeting a protein called human leucocyte antigen G (HLA-G) that is found in high levels on some cancer cells. By attaching itself to this protein it may help the immune system to attack and kill the cancer cells.

The four main aims of the clinical trial are to find out:

1. The best dose of UCB4594 that can be given safely to participants in the trial. 2. What the side effects of UCB4594 are and how they can be managed. 3. What happens to UCB4594 inside the body and how it affects cancer cells. 4. Whether UCB4594 can cause cancer to shrink.

What does the study involve?

This clinical trial is split into two phases.

Phase I (Module A) is the 'dose escalation' phase. This is where small groups of participants receive UCB4594 at a certain dose level starting with a low dose level. After reviewing the results obtained at each dose level, it will be decided whether or how much to increase the dose for the next group of participants. This part of the study aims to find the best dose to give that does not cause too many side effects.

Phase II is the 'dose expansion' phase. This starts when the dose escalation phase has worked out the best dose of UCB4594 to give. In this part of the trial UCB4594 will be given alone (Module B) or in combination with other anti-cancer drugs (Module C). This will allow us to find out more about how the drug is working and whether UCB4594 affects cancer. Details for Module C of the dose expansion phase will be added when the types of cancer and anti-cancer drugs are defined.

What are the possible benefits and risks of participating?

UCB4594 is a new drug that has never been given to humans before. Possible risks and benefits are based on laboratory tests and experience with similar drugs but there is not yet any information about the effects of UCB4594 in humans. Participants in the trial will be monitored closely to find out the effects of UCB4594.

Eligibility

Relevant conditions:

Advanced Solid Tumours

Squamous Cell Carcinoma of Head and Neck

Carcinoma, Non-Small-Cell Lung

Colorectal Neoplasms

Triple Negative Breast Neoplasms

Carcinoma, Renal Cell (Clear Cell Only)

Esophageal Neoplasms

Stomach Neoplasms (Excluding Gastrointestinal Stromal Tumors)

Uterine Cervical Neoplasms

Ovarian Neoplasms

Pancreatic Neoplasms

If you aren't sure if you meet the criteria above speak to your healthcare professional. Criteria may be updated but not reflected here, do not hesitate to contact the study if you think are close to fitting criteria.

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Contact Information

Overall Contact

Fiona Thistlethwaite, Prof

fiona.thistlethwaite@nhs.net

+44 (0)161 9187672

Data sourced from ClinicalTrials.gov