738348
Last Update Posted: 2012-06-08
Recruiting has ended
All Genders accepted | Under |
50 Estimated Participants | No Expanded Access |
Interventional Study | Accepts healthy volunteers |
Effect of Perioperative Sivelstat Administration for Liver Resection
It is reported that sivelstat improved and preserved the postoperative renal function in the orthopedic management. Moreover because sivelstat reduced the migration of neutrophil, it improved acute lung injury. During liver resection, Pringle maneuver, clamping the hepatoduodenal ligament, was performed. Pringle maneuver causes reperfusion injury of the liver. We have a hypothesis that sivelstat prevent the warm shock of reperfusion injury of the liver by Pringle maneuver.
Whether the incidence of postoperative morbidities, such as liver failure, renal failure, or congestive heart failure, was reduced by administration of perioperative sivelstat.
Eligibility
Relevant conditions:
Liver Diseases
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Data sourced from ClinicalTrials.gov