745446
Last Update Posted: 2008-09-05
Recruiting has ended
Males accepted | 18 Years-35 Years |
18 Estimated Participants | No Expanded Access |
Interventional Study | Accepts healthy volunteers |
The Effect of a Retrofit Particle Trap on the Vascular Effects of Diesel Exhaust Inhalation
The purpose of this study is to determine whether a retrofit particle trap can reduce the adverse vascular responses to diesel exhaust inhalation
18 subjects healthy male volunteers will be recruited at Umeå University. In a randomised, double blind 3 way crossover trial, subjects will be exposed to filtered air, diesel exhaust (300mcg/m3) or filtered diesel exhaust for 1 hour during intermittent exercise.
2 hours following the exposure, thrombogenicity will be assessed using the Badimon chamber - an ex-vivo model of thrombosis formed under constant flow conditions.
Forearm blood flow in response to infused intra-brachial vasodilators will be measured using venous occlusion plethysmography 6 hours after the exposure.
Arterial stiffness will be measured using peripheral arterial applanation tonometry in the hour post-exposure.
Blood samples will be collected at timepoints over the 24 hours after exposure.
Eligibility
Relevant conditions:
Heart Disease
If you aren't sure if you meet the criteria above speak to your healthcare professional. Criteria may be updated but not reflected here, do not hesitate to contact the study if you think are close to fitting criteria.
locations
Data sourced from ClinicalTrials.gov