753493
Last Update Posted: 2019-07-18
Recruiting has ended
All Genders accepted | 18 Years + |
20 Estimated Participants | No Expanded Access |
Interventional Study | Does not accept healthy volunteers |
Pharmacokinetics and Safety of Intravenous Topiramate in Adult Patients
The aims of this study are to determine, in adult patients on maintenance topiramate therapy, the steady-state pharmacokinetics and safety of orally and intravenously administered topiramate.
The long-term goal of this research project is to develop a more effective, safer therapy for neonatal seizures. Prior to using an investigational intravenous topiramate formulation in children and neonates, the pharmacokinetics and safety of the formulation must be demonstrated in adults. The immediate aims of this study are to determine the pharmacokinetics and safety of a novel intravenous topiramate formulation. An additional aim is to determine if sex, advancing age, or genotype affects topiramate absorption, distribution, or elimination.
Eligibility
Relevant conditions:
Epilepsy
Migraines
If you aren't sure if you meet the criteria above speak to your healthcare professional. Criteria may be updated but not reflected here, do not hesitate to contact the study if you think are close to fitting criteria.
locations
Data sourced from ClinicalTrials.gov